Name: TRβ1 Polyclonal Antibody
SKU: WP14875
Price: 268 USD
Availability: InStock

Product details

Background:

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	TRβ1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	53kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human Thyroid Hormone Receptor beta. AA range:11-60
Specificity	TRβ1 Polyclonal Antibody detects endogenous levels of TRβ1 protein.
Gene Name	THRB
Protein Name	Thyroid hormone receptor beta
Other Name	THRB; / ERBA2; / NR1A2; / THR1; / Thyroid hormone receptor beta; / Nuclear receptor subfamily 1 group A member 2; / c-erbA-2; / c-erbA-beta
Species	Human
Gene ID	7068
Uniprot	P10828,
Species.1	Mouse
Gene ID.1	21834
Uniprot.1	P37242,
Species.2	Rat
Gene ID.2
Uniprot.2	P18113
Cellular Localization	Nucleus.
Tissue Expression	Brain,Kidney,Pituitary,Placenta,Testis,
Signaling_pathway	Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway
Research Areas	>>Neuroactive ligand-receptor interaction; / >>Thyroid hormone signaling pathway
Function	Disease:Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).,Disease:Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also called familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.,Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:High affinity receptor for triiodothyronine.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with NOCA7 in a ligand-inducible manner. Interacts with C1D.,