Troponin I-C Polyclonal Antibody
Ucallm_WP14866-50
Price range: $268.00 through $328.00
Product details
Background:
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: tnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Specifications
| Size | 50μL/100μL |
| Target | Troponin I-C |
| Reactivity | Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 28kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from mouse TNNI3. AA range:5-54 |
| Specificity | Troponin I-C Polyclonal Antibody detects endogenous levels of Troponin I-C protein. |
| Gene Name | TNNI3 |
| Protein Name | Troponin I cardiac muscle |
| Other Name | TNNI3; / TNNC1; / Troponin I; / cardiac muscle; / Cardiac troponin I |
| Species | Human |
| Gene ID | 7137 |
| Uniprot | P19429, |
| Species.1 | Mouse |
| Gene ID.1 | 21954 |
| Uniprot.1 | P48787, |
| Species.2 | Rat |
| Gene ID.2 | 29248 |
| Uniprot.2 | P23693 |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | |
| Function |
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