TRPM7 Polyclonal Antibody
Ucallm_WP1863-50
Price range: $268.00 through $328.00
Product details
Background:
transient receptor potential cation channel subfamily M member 7(TRPM7) Homo sapiens The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Specifications
| Size | 50μL/100μL |
| Target | TRPM7 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 205kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TRPM7 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TRPM7 CHAK1 LTRPC7 |
| Protein Name | Transient receptor potential cation channel subfamily M member 7 (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) |
| Other Name | |
| Species | Human |
| Gene ID | 54822 |
| Uniprot | Q96QT4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q923J1, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q925B3 |
| Cellular Localization | Membrane; Multi-pass membrane protein . |
| Tissue Expression | Colon,Liver,Placenta, |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Necroptosis;Cellular Processes >> Cell growth and death >> Cellular senescence;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway |
| Research Areas | >>Necroptosis; / >>Cellular senescence; / >>NOD-like receptor signaling pathway; / >>Mineral absorption |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Binds 1 zinc ion per subunit.,Disease:Defects in TRPM7 influence susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 [MIM:105500]; also called amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodegenerative disorder with unusually high incidence among the Chamorro people of the Western Pacific Islands of Guam. Both amyotrophic lateral sclerosis and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual.,Function:Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).,PTM:Autophosphorylated.,similarity:Contains 1 alpha-type protein kinase domain.,similarity:In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.,similarity:In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily.,subunit:Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6., |
Please login to post questions
Related products
