Product details
Background:
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TTC5 rabbit pAb
Ucallm_WP4299-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TTC5 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 48kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TTC5 AA range: 82-132 |
| Specificity | This antibody detects endogenous levels of TTC5 at Human/Mouse/Rat |
| Gene Name | TTC5 |
| Protein Name | TTC5 |
| Other Name | |
| Species | Human |
| Gene ID | 91875 |
| Uniprot | Q8N0Z6, |
| Species.1 | Mouse |
| Gene ID.1 | 219022 |
| Uniprot.1 | Q99LG4, |
| Species.2 | Rat |
| Gene ID.2 | 305837 |
| Uniprot.2 | Q5BK48 |
| Cellular Localization | Nucleus . Cytoplasm . Cytoplasmic vesicle . Mitochondrion matrix . Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm. Nuclear localization may be necessary for DNA damage-dependent stabilization of the protein. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2.,PTM:Phosphorylation at Ser-203 enhances protein stability, regulates nuclear accumulation and association with p300/EP300.,similarity:Contains 4 TPR repeats.,subcellular location:Phosphorylation at Ser-203 results in nuclear localization, while unphosphorylated protein localizes to the cytoplasm.,subunit:Interacts with JMY and p300/EP300., |
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