TTF-I Polyclonal Antibody
Ucallm_WP14890-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011],
Specifications
| Size | 50μL/100μL |
| Target | TTF-1 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 103kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TTF1. AA range:10-59 |
| Specificity | TTF-1 Polyclonal Antibody detects endogenous levels of TTF-1 protein. |
| Gene Name | TTF-1 |
| Protein Name | AV026640; BCH; Benign chorea; BHC; Homeobox protein NK 2 homolog A; Homeobox protein NK-2 homolog A; Homeobox protein Nkx 2.1; Homeobox protein Nkx-2.1; Homeobox protein Nkx2.1; NK 2; NK 2 homolog A; NK2; NK2 homeobox 1; NK2, drosophila, homolog of, A; NK2.1, mouse, homolog of; Nkx 2 1; NKX 2.1; NKX 2A; NKX2 1; Nkx2-1; NKX2.1; NKX21_HUMAN; NKX2A; T EBP; T/EBP; TEBP; Thyroid nuclear factor 1; Thyroid nuclear factor; Thyroid specific enhancer binding protein; Thyroid transcription factor 1; Tin man; Tinman; TITF 1; TITF1; TTF 1; TTF-1; TTF1 |
| Other Name | TTF1; / Transcription termination factor 1; / TTF-1; / RNA polymerase I termination factor; / Transcription termination factor I; / TTF-I |
| Species | Human |
| Gene ID | 7270 |
| Uniprot | Q15361, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q62187 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Nucleus, nucleolus . |
| Tissue Expression | Epithelium,Uterus, |
| Signaling_pathway | |
| Research Areas | >>Thyroid hormone synthesis |
| Function | Domain:The N-terminal region inhibits DNA-binding via its interaction with the C-terminal region.,Function:Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with TIP5 recovers DNA-binding activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,sequence Caution:Contaminating sequence. Sequence of unknown origin in the C-terminal part.,sequence Caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 2 Myb-like domains.,subunit:Oligomer. The oligomeric structure enables to interact simultaneously with two separate DNA fragments. Interacts with TIP5., |
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