Price range: $268.00 through $328.00
Background:
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | TTL |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 41kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TTL AA range: 160-210 |
| Specificity | This antibody detects endogenous levels of TTL at Human/Mouse/Rat |
| Gene Name | TTL |
| Protein Name | TTL |
| Other Name | |
| Species | Human |
| Gene ID | 150465 |
| Uniprot | Q8NG68, |
| Species.1 | Mouse |
| Gene ID.1 | 69737 |
| Uniprot.1 | P38585, |
| Species.2 | Rat |
| Gene ID.2 | 171572 |
| Uniprot.2 | Q9QXJ0 |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate.,cofactor:Magnesium.,cofactor:Potassium.,Function:Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.,similarity:Belongs to the tubulin--tyrosine ligase family.,similarity:Contains 1 TTL domain.,subunit:Monomer., |
