Name: U-Blot® Actin, smooth muscle (SMA) Mouse mAb (Ready to Use)
SKU: WM1641R
Price: 168 USD
Availability: InStock

U-Blot® Actin, smooth muscle (SMA) Mouse mAb (Ready to Use)

Ucallm_WM1641R

$168.00

Product details

Background：
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008],

Specifications

Size	6mL
Target	Actin_smooth muscle (SMA)
Reactivity	Human, Mouse, Rat
Applications	IHC
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage	2°C to 8°C/1 year,Ship by ice bag
Concentration
Clonality	Monoclonal
Clone Number	RMM-SMA
Immunogen	Synthesized peptide derived from human Actin, smooth muscle (SMA) AA range: 1-100
Specificity	The antibody can specifically recognize smooth muscle actin and shows no reaction with actin of skelatal muscle or cardiac muscle.
Gene Name	ACTA2/ACTG2
Protein Name	Actin, smooth muscle
Other Name
Species	Human
Gene ID
Uniprot	P62736;P63267
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasmic
Tissue Expression	Pituitary,Uterus,
Signaling_pathway
Research Areas	>>Vascular smooth muscle contraction; / >>Apelin signaling pathway; / >>Relaxin signaling pathway
Function	Disease:Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,Function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the actin family.,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.,