Product details
Background：
function:Plays a role in autophagy. ,similarity:Belongs to the ATG9 family. ,
U-Blot® ATG9A Rabbit mAb
Ucallm_WR5934-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | Atg9a |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 94kD |
| MW(Observed) | 100-110kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:10000-1:50000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1883R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | ATG9A APG9L1 |
| Protein Name | Atg9a |
| Other Name | ATG9 autophagy related 9 homolog A; / S. cerevisiae |
| Species | Human |
| Gene ID | 79065 |
| Uniprot | Q7Z3C6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q68FE2, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q5FWU3 |
| Cellular Localization | Preautophagosomal structure membrane; Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein . Late endosome membrane; Multi-pass membrane protein . Recycling endosome membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane; Multi-pass membrane protein . Mitochondrion membrane; Multi-pass membrane protein . Mainly localizes to the trans-Golgi network (TGN) and the endosomal system; cycles between them though vesicle trafficking (PubMed:27316455, PubMed:27663665). Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex (PubMed:29180427, PubMed:30262884). Under amino acid starvation or rapamycin treatment, redistributes to preautophagosomal structure/phagophore assembly site (PAS) (PubMed:16940348). The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1 (PubMed:16940348). Upon autophagy induction, a small portion transiently localizes to the autophagic membranes (PubMed:22456507). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599). . |
| Tissue Expression | Brain,Embryo,Epithelium,Fetal brain,Lung endothelial cell,Lymph,Rectum tumor,Testis |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal |
| Research Areas | >>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal |
| Function | Function:Plays a role in autophagy.,similarity:Belongs to the ATG9 family., |
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