Product details
Background：
U-Blot® BCL11A Rabbit mAb
Ucallm_WR6017-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | BCL11A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 91kD |
| MW(Observed) | 125kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1944R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | BCL11A CTIP1 EVI9 KIAA1809 ZNF856 |
| Protein Name | B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) |
| Other Name | |
| Species | Human |
| Gene ID | 53335 |
| Uniprot | Q9H165, |
| Species.1 | Mouse |
| Gene ID.1 | 14025 |
| Uniprot.1 | Q9QYE3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Chromosome . Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). .; [Isoform 1]: Nucleus matrix . Colocalizes with BCL6 in nuclear paraspeckles. .; [Isoform 2]: Cytoplasm . Nucleus . Predominantly localized in the nucleus in nuclear paraspeckles. .; [Isoform 3]: Cytoplasm . Nucleus . Predominantly localized in the cytoplasm in the absence of interaction with isoform 1 and isoform 2. In presence of isoform 1 or isoform 2, translocates from the cytoplasm into nuclear paraspeckles. . |
| Tissue Expression | Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development.; [Isoform 1]: Expressed in fetal and adult brain, and in the plasmacytoid dendritic cell. |
| Signaling_pathway | |
| Research Areas | |
| Function | Transcription factor . Associated with the BAF SWI/SNF chromatin remodeling complex . Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene . Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level . Involved in brain development . May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity). |
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