SKU: WR5969 Categories: ,

U-Blot® CD48 Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR5969-50
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Product details

Background:
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells , dendritic cells and endothelial cells , and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain , however , but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Dec 2011] ,

Specifications

Size50μL/100μL
TargetCD48
ReactivityHuman
ApplicationsWB, IHC, IF, IP, ELISA
MW(Calculated)28kD
MW(Observed)43kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRM1851R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
SpecificityEndogenous
Gene NameCD48
Protein NameCD48 antigen
Other NameCD48; / BCM1; / BLAST1; / CD48 antigen; / B-lymphocyte activation marker BLAST-1; / BCM1 surface antigen; / Leukocyte antigen MEM-102; / TCT.1; / CD48
SpeciesHuman
Gene ID962
UniprotP09326,
Species.1Mouse
Gene ID.1
Uniprot.1P18181
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Lipid-anchor, GPI-anchor . Secreted .
Tissue ExpressionWidely expressed on all hematopoietic cells.
Signaling_pathwayOrganismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Research Areas>>Natural killer cell mediated cytotoxicity
FunctionFunction:Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,
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