Specifications
| Size | 50μL/100μL |
| Target | CD80 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 65kD |
| MW(Observed) | 60-70kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1699R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | CD80 CD28LG CD28LG1 LAB7 |
| Protein Name | T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80) |
| Other Name | CD80; / CD28LG; / CD28LG1; / LAB7; / T-lymphocyte activation antigen CD80; / Activation B7-1 antigen; / BB1; / CTLA-4 counter-receptor B7.1; / B7; / CD antigen CD80 |
| Species | Human |
| Gene ID | 941 |
| Uniprot | P33681, |
| Species.1 | Mouse |
| Gene ID.1 | 12519 |
| Uniprot.1 | Q00609 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Expression | Expressed on activated B-cells, macrophages and dendritic cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> Intestinal immune network for IgA production;Human Diseases >> Immune disease >> Systemic lupus erythematosus;Human Diseases >> Immune disease >> Rheumatoid arthritis;Human Diseases >> Immune disease >> Autoimmune thyroid disease;Human Diseases >> Immune disease >> Allograft rejection;Human Diseases >> Immune disease >> Graft-versus-host disease;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules; / >>Toll-like receptor signaling pathway; / >>Intestinal immune network for IgA production; / >>Type I diabetes mellitus; / >>Autoimmune thyroid disease; / >>Systemic lupus erythematosus; / >>Rheumatoid arthritis; / >>Allograft rejection; / >>Graft-versus-host disease; / >>Viral myocarditis |
| Function | Function:Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.,tissue specificity:Expressed on activated B-cells, macrophages and dendritic cells., |
