SKU: WR5726 Categories: ,

U-Blot® Dvl-2 Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR5726-100
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Product details

Background:This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008],

Specifications

TargetDvl-2
ReactivityHuman,Mouse,Rat
ApplicationsWB,IHC,IF,IP,ELISA
MW(Calculated)79kD
MW(Observed)90kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Modified site
Recommended Dilution RatioIHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
CompositionPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification ProcessProtein A
Purity
Storage Condition-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberPT1583R
Immunogen
Sequence
SpecificityEndogenous
Gene NameDVL2
Protein NameSegment polarity protein dishevelled homolog DVL-2
AliasDVL2;Segment polarity protein dishevelled homolog DVL-2;Dishevelled-2;DSH homolog 2
Organism-1Human
Gene ID-11856
SwissProt-1O14641
Organism-2Mouse
GeneID-213543.0
SwissProt-2Q60838
Organism-3
GeneID-3
SwissProt-3
Organism-4
GeneID-4
SwissProt-4
Cellular LocalizationCell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol . Cytoplasmic vesicle . Nucleus . Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136). .
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