U-Blot® FIG4 Rabbit mAb
Ucallm_WR6009-50
Price range: $268.00 through $328.00
Product details
Background：
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain , approximately 400 amino acids in length and consisting of seven conserved motifs , has been shown to possess phosphoinositide phosphatase activity. The yeast homolog , Sac1p , is involved in the regulation of various phosphoinositides , and affects diverse cellular functions such as actin cytoskeleton organization , Golgi function , and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease , type 4J. [provided by RefSeq , Jul 2008] ,
Specifications
| Size | 50μL/100μL |
| Target | FIG4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 104kD |
| MW(Observed) | 95kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1943R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | FIG4 KIAA0274 SAC3 |
| Protein Name | FIG4 |
| Other Name | Polyphosphoinositide phosphatase; / Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; / SAC domain-containing protein 3 |
| Species | Human |
| Gene ID | 9896 |
| Uniprot | Q92562, |
| Species.1 | Mouse |
| Gene ID.1 | 103199 |
| Uniprot.1 | Q91WF7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endosome membrane . Localization requires VAC14 and PIKFYVE. . |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Inositol phosphate metabolism; / >>Metabolic pathways; / >>Amyotrophic lateral sclerosis; / >>Pathways of neurodegeneration - multiple diseases |
| Function | phospholipid metabolic process, glycerophospholipid metabolic process, vacuole organization, behavior, locomotory behavior, cell death, death, organophosphate metabolic process, neuron differentiation, phosphoinositide metabolic process, pigmentation, glycerolipid metabolic process, neuron development, |
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