Name: U-Blot® Filaggrin Rabbit mAb
SKU: WR5245
Price: 268 USD
Availability: InStock

U-Blot® Filaggrin Rabbit mAb

Ucallm_WR5245-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR5245-100

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Background:The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009],

Specifications

Size	50μL/100μL
Target	Filaggrin
Reactivity	Human
Applications	IHC, IF, ELISA
MW(Calculated)
MW(Observed)
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:500; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1486R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	FLG
Protein Name	Filaggrin
Other Name
Species	Human
Gene ID	2312
Uniprot	P20930
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasmic granule . In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719). .
Tissue Expression	Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417).
Signaling_pathway
Research Areas
Function	Disease:Defects in FLG are the cause of ichthyosis vulgaris (VI) [MIM:146700]; also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever.,Disease:Defects in FLG may be the cause of susceptibility to atopic dermatitis type 2 (ATOD2) [MIM:605803]. Atopic dermatitis, also known as eczema commonly begins in infancy or early childhook and is characterized by ichy and inflamed skin.,Function:Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.,PTM:Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.,PTM:Undergoes deimination of some arginine residues (citrullination).,similarity:Belongs to the S100-fused protein family.,similarity:Contains 2 EF-hand domains.,similarity:Contains 23 filaggrin repeats.,tissue specificity:Keratohyalin granules.,

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U-Blot® Filaggrin Rabbit mAb

Product details

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U-Blot® Filaggrin Rabbit mAb

Product details

Specifications

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