U-Blot® Histone H3 (Acetyl Lys56) Rabbit mAb

Background:Histone H3 forms tetramers with H4 to build chromatin skeleton. Its N-tail and core lysine residues undergo reversible acetylation regulated by HAT and HDAC. Acetylation neutralizes positive charge, relaxes chromatin and recruits bromodomain co-activators. Different acetyl sites on H3 separately control transcription, DNA repair, cell cycle and replication. H3K56ac lies inside nucleosome core, catalyzed by Rtt109/TIP60. It regulates chromatin assembly after DNA replication and DNA double-strand break repair. Loss of H3K56ac causes genome instability and cell cycle arrest.