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Background：
Histone H3 forms H3-H4 tetramers as nucleosome core scaffold. Lysine dimethylation is a reversible epigenetic modification controlled by methyltransferases and demethylases. Different dimethyl marks recruit specific reader proteins to regulate poised transcription, heterochromatin formation, DNA repair and cell differentiation. Each lysine site on H3 carries unique biological functions. H3K23me2 responds to intracellular metabolic signals and accumulates at stress response gene loci. It regulates chromatin remodeling after DNA double-strand break and stabilizes genome integrity.
