- Please choose product options by visiting U-Blot™ Detergent-Free Protein Extraction Kit for Animal Cultured Cells and Tissues.
U-Blot® MCT4 Rabbit mAb
Ucallm_WR5911-50
Price range: $268.00 through $328.00
Product details
Background：
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family , which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics , which are related to the metabolic requirements of the tissues in which it is found. The MCTs , which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654) , are characterized by 12 predicted transmembrane domains (Price et al. , 1998 [PubMed 9425115]) .[supplied by OMIM , Mar 2008] ,
Specifications
| Size | 50μL/100μL |
| Target | MCT4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 49kD |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1861R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | SLC16A3 |
| Protein Name | Monocarboxylate transporter 4 |
| Other Name | SLC16A3; / MCT4; / Monocarboxylate transporter 4; / MCT 4; / Solute carrier family 16 member 3 |
| Species | Human |
| Gene ID | 9123 |
| Uniprot | O15427, |
| Species.1 | Mouse |
| Gene ID.1 | 80879 |
| Uniprot.1 | P57787, |
| Species.2 | Rat |
| Gene ID.2 | 80878 |
| Uniprot.2 | O35910 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Highly expressed in skeletal muscle. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer |
| Research Areas | >>Central carbon metabolism in cancer |
| Function | Function:Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.,similarity:Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.,tissue specificity:Highly expressed in skeletal muscle., |
Please login to post questions
Related products
