Price range: $268.00 through $328.00
Background：
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al. , 1993 [PubMed 8314572]) . Members of this family contain the POU domain , a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM , Jul 2010] ,
| Size | 50μL/100μL |
| Target | OCT1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 77kD |
| MW(Observed) | 90kD |
| Host Species | Rabbit |
| Isotype | IgG, Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year (Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM2040R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | POU2F1 |
| Protein Name | POU domain class 2 transcription factor 1 |
| Other Name | POU2F1; / OCT1; / OTF1; / POU domain; / class 2,transcription factor 1; / NF-A1; / Octamer-binding protein 1; / Oct-1; / Octamer-binding transcription factor 1; / OTF-1 |
| Species | Human |
| Gene ID | 5451 |
| Uniprot | P14859, |
| Species.1 | Mouse |
| Gene ID.1 | 18986 |
| Uniprot.1 | P25425 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | Ubiquitous. Isoform 2 is lymphocyte-specific. |
| Signaling_pathway | |
| Research Areas | >>Herpes simplex virus 1 infection; / >>Lipid and atherosclerosis |
| Function | Function:Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1 , AR and PGR. ,PTM:Phosphorylated by PRKDC. ,similarity:Belongs to the POU transcription factor family. Class-2 subfamily. ,similarity:Contains 1 homeobox DNA-binding domain. ,similarity:Contains 1 POU-specific domain. ,subunit:Interacts with NR3C1 , AR , PGR and HCFC1. ,tissue specificity:Ubiquitous. Isoform 2 is lymphocyte-specific. , |
