Name: U-Blot® p57kip2 Mouse mAb (Ready to Use)
SKU: WM1761R
Price: 168 USD
Availability: InStock

Product details

Background：
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],

Specifications

Target	p57
Reactivity	Human, Mouse, Rat
Applications	IHC
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	IgG2b,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Source
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Purity
Storage	2°C to 8°C/1 year,Ship by ice bag
Concentration
Clonality	Monoclonal
Clone Number	ABT214
Immunogen	Synthesized peptide derived from human p57kip2 AA range: 200-316
Sequence
Specificity	The antibody can specifically recognize human p57kip2 protein.
Gene Name	CDKN1C KIP2
Protein Name	Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip 2; p57KIP2; WBS
Other Name	Beckwith Wiedemann syndrome; / BWCR; / BWS; / CDKI; / CDKN 1C; / CDKN1C; / CDN1C_HUMAN; / Cyclin dependent kinase inhibitor 1C; / Cyclin dependent kinase inhibitor p57; / Cyclin-dependent kinase inhibitor 1C; / Cyclin-dependent kinase inhibitor p57; / KIP 2; / KIP2; / p57; / p57 Kip 2; / p57KIP2; / WBS
Species	Human
Gene ID-1	1028
Uniprot	P49918,
Species.1	Mouse
Gene ID-2
Uniprot.1	P49919
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],
Cellular Localization	Nuclear
Tissue Expression	Placenta/ Kindey
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle
Research Areas	>>Cell cycle
Function	Disease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,Disease:Defects in CDKN1C are involved in tumor formation.,Function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.,
RRID