U-Blot® Pan-Tri-Methyllysine Rabbit pAb
Ucallm_WT9182-100
Price range: $450.00 through $1,150.00
Product details
Background:Histones undergo a wide range of enzyme-catalyzed post-translational modifications, including acetylation, methylation, phosphorylation and ubiquitination. Lysine trimethylation is a vital epigenetic modification that predominantly occurs on histone lysine residues. It is dynamically regulated by histone methyltransferases and demethylases, and extensively distributed in eukaryotic chromatin.Lysine trimethylation participates in governing chromatin structure remodeling, transcriptional activation or repression, cell cycle regulation, and DNA damage repair. Abnormal trimethylation levels are closely associated with tumorigenesis, developmental disorders, inflammation and neurodegenerative diseases, acting as a pivotal molecular marker for epigenetic research and disease mechanism investigation.
Specifications
| Target | Tri-Methyllysine |
| Reactivity | Species Independent |
| Application | ELISA, WB, IP, IF, IAC |
| MW(Calculated) | Multiple |
| MW(Observed) | Multiple |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Modification | Lysine Trimethylation |
| Modification Site | Lys（K） |
| Recommended dilution ratio | ELISA 1:2000;WB 1:2000;IP 5 µg/mg protein sample;IF 5 µg/mL or 1:100 |
| Composition | 250ug/mL antibody stored in PBS, 50% glycerol |
| Purification process | N-(epsilon) trimethyllysine on agarose and immunoaffinity absorbed with N-(epsilon) methylated lysine and N-(epsilon) dimethylated lysine on agarose |
| Storage | Product is stable for several weeks at 4°C. For extended storage, store product at –20ºC. |
| Stability | Stable for 12 months from date of receipt / reconstitution. |
| Concentration | |
| Clonal | Polyclonal |
| Clone Number | |
| Immunogen | Methylated KLH conjugates |
| Gene Name | |
| Protein Name | |
| Alternative name | Kme3 |
| Organism-1 | |
| Gene ID | |
| SwissProt-1 | |
| Cellular Localization |
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