Specifications
| Size | 50μL/100μL |
| Target | PD-L2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA, IHC |
| MW(Calculated) | 31kD |
| MW(Observed) | 28kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:200-1:1000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IHC 1:50-1:200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1804R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | PDCD1LG2 B7DC CD273 PDCD1L2 PDL2 |
| Protein Name | Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273) |
| Other Name | Programmed cell death 1 ligand 2; / PD-1 ligand 2; / PD-L2; / PDCD1 ligand 2; / Programmed death ligand 2; / Butyrophilin B7-DC; / B7-DC; / CD antigen CD273 |
| Species | Human |
| Gene ID | 80380 |
| Uniprot | Q9BQ51, |
| Species.1 | Mouse |
| Gene ID.1 | 58205 |
| Uniprot.1 | Q9WUL5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 3]: Secreted .; [Isoform 2]: Endomembrane system; Single-pass type I membrane protein .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein . |
| Tissue Expression | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | >>Cell adhesion molecules |
| Function | Function:Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.,induction:Up-regulated by IFNG stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4.,similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PDCD1.,tissue specificity:Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus., |
