Price range: $268.00 through $328.00
Background:This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
| Size | 50μL/100μL |
| Target | Rag C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IP, ELISA |
| MW(Calculated) | 44kD |
| MW(Observed) | 54kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1589R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | RRAGC |
| Protein Name | Ras-related GTP-binding protein C |
| Other Name | RRAGC; / Ras-related GTP-binding protein C; / Rag C; / RagC; / GTPase-interacting protein 2; / TIB929 |
| Species | Human |
| Gene ID | 64121 |
| Uniprot | Q9HB90, |
| Species.1 | Mouse |
| Gene ID.1 | 54170 |
| Uniprot.1 | Q99K70 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). . |
| Tissue Expression | Lymph,Ovary, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway |
| Research Areas | >>Autophagy - animal; / >>mTOR signaling pathway; / >>Shigellosis |
| Function | Function:Has guanine nucleotide-binding activity but weak intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.,subunit:Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB., |
