U-Blot® Research Grade Fontolizumab
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$9,999.00
Product details
Background：Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH).
• Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation., PMID:33606996
• Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy., PMID:37275859
• IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption., PMID:31566580
• IFN-γ Contributes to the Immune Mechanisms of Hypertension., PMID:36591357
• Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop., PMID:33766856
• Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche., PMID:29950724
• IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies., PMID:34906138
• Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism., PMID:29787713
• Restraint of IFN-γ expression through a distal silencer CNS-28 for tissue homeostasis., PMID:37040761
• MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer., PMID:33495298
Specifications
| Target | Interferon gamma |
| Reactivity | Human |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Humanized |
| Isotype | IgG1-nd |
| Conjugate/Modification | |
| Modification | |
| Recommended Dilution Ratio | |
| Composition | 0.01M PBS, pH 7.4. |
| Purification Process | Protein A/G purified from cell culture supernatant. |
| Purity | >95% as determined by SDS-PAGE. |
| Storage Condition | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Mammalian Cells |
| Gene Name | |
| Protein Name | |
| Alias | Interferon gamma, IFN-gamma, Immune interferon, IFNG |
| Species | |
| Gene ID-1 | P01579 |
| Uniprot | |
| Species.1 | |
| Gene ID | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.1 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Description | Background：Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH).<br>• Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation., PMID:33606996<br />• Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy., PMID:37275859<br />• IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption., PMID:31566580<br />• IFN-<i>γ</i> Contributes to the Immune Mechanisms of Hypertension., PMID:36591357<br />• Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop., PMID:33766856<br />• Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche., PMID:29950724<br />• IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies., PMID:34906138<br />• Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism., PMID:29787713<br />• Restraint of IFN-γ expression through a distal silencer CNS-28 for tissue homeostasis., PMID:37040761<br />• MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer., PMID:33495298<br /> |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function |
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