U-Blot® Research Grade Landogrozumab
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Product details
Background：Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.
• Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454
• Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826
• GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905
• Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196
• Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042
• Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097
• Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925
• Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254
• Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022
• Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202
Specifications
| Target | GDF-8 |
| Reactivity | Human |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Humanized |
| Isotype | IgG4-kappa |
| Conjugate/Modification | |
| Modification | |
| Recommended Dilution Ratio | |
| Composition | 0.01M PBS, pH 7.4. |
| Purification Process | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Storage Condition | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Mammalian Cells |
| Gene Name | |
| Protein Name | |
| Alias | GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8 |
| Species | |
| Gene ID-1 | O14793 |
| Uniprot | |
| Species.1 | |
| Gene ID | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.1 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Description | Background：Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.<br>• Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454<br />• Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826<br />• GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905<br />• Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196<br />• Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042<br />• Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097<br />• Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925<br />• Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254<br />• Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022<br />• Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202<br /> |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function |
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