Name: U-Blot® Research Grade Tinurilimab
SKU: WA3666
Price: 9999 USD
Availability: InStock

Product details

Background：Tinurilimab (Bay 1834942) is an anti-CEACAM6 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors.
• Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression., PMID:29110374
• Analysis of heterophilic cell adhesion mediated by CD66b and CD66c using their soluble recombinant proteins., PMID:8645267
• Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)., PMID:16204051
• Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas., PMID:10666389
• [Nonspecific cross-reacting antigen (NCA)]., PMID:16149618
• Purification and characterization of a 95-kDa protein–carcinoembryonic antigen-related cell adhesion molecule 8–from normal human granulocytes., PMID:12379336
• The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells., PMID:10374883
• Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils., PMID:8543346
• Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers., PMID:17201906
• Bile carcinoembryonic cell adhesion molecule 6 (CEAM6) as a biomarker of malignant biliary stenoses., PMID:23806607

Specifications

Target	CD66
Reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Humanized
Isotype	IgG1-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality	Monoclonal
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	Normal cross-reacting antigen, Carcinoembryonic antigen-related cell adhesion molecule 6, CEACAM6, CD66c, NCA, Non-specific crossreacting antigen
Species
Gene ID-1	P40199
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Tinurilimab (Bay 1834942) is an anti-CEACAM6 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors.<br>• Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression., PMID:29110374<br />• Analysis of heterophilic cell adhesion mediated by CD66b and CD66c using their soluble recombinant proteins., PMID:8645267<br />• Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)., PMID:16204051<br />• Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas., PMID:10666389<br />• [Nonspecific cross-reacting antigen (NCA)]., PMID:16149618<br />• Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes., PMID:12379336<br />• The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells., PMID:10374883<br />• Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils., PMID:8543346<br />• Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers., PMID:17201906<br />• Bile carcinoembryonic cell adhesion molecule 6 (CEAM6) as a biomarker of malignant biliary stenoses., PMID:23806607<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function