Name: U-Blot® RORγ Rabbit mAb
SKU: WR5264
Price: 268 USD
Availability: InStock

U-Blot® RORγ Rabbit mAb

Ucallm_WR5264-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5264-100

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Product details

Background:The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	RORγ
Reactivity	Mouse
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	58kD
MW(Observed)	58kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1506R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	RORC
Protein Name	Nuclear receptor ROR-gamma
Other Name	RORC; / NR1F3; / RORG; / RZRG; / Nuclear receptor ROR-gamma; / Nuclear receptor RZR-gamma; / Nuclear receptor subfamily 1 group F member 3; / Retinoid-related orphan receptor-gamma
Species	Human
Gene ID	6097
Uniprot	P51449,
Species.1	Mouse
Gene ID.1	19885
Uniprot.1	P51450
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus .
Tissue Expression	Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Signaling_pathway	Organismal Systems >> Immune system >> Th17 cell differentiation;Organismal Systems >> Environmental adaptation >> Circadian rhythm;Human Diseases >> Immune disease >> Inflammatory bowel disease
Research Areas	>>Th17 cell differentiation; / >>Circadian rhythm; / >>Inflammatory bowel disease
Function	Function:Orphan nuclear receptor.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:Highly expressed in skeletal muscle.,