SKU: WM1629R Categories: ,

U-Blot® Somatostatin Mouse mAb (Ready to Use)

$168.00

SKU: WM1629R
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Product details

Background:
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008],

Specifications

TargetSomatostatin
ReactivityHuman, Mouse, Rat
ApplicationsIHC
MW(Calculated)
MW(Observed)
Host SpeciesMouse
IsotypeIgG2b,Kappa
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioReady to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationThe prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Source
PurificationThe antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Purity
Storage2°C to 8°C/1 year,Ship by ice bag
Concentration
ClonalityMonoclonal
Clone NumberABT232
ImmunogenSynthesized peptide derived from human Somatostatin AA range: 50-116
Sequence
SpecificityThe antibody can specifically recognize human Somatostatin protein.
Gene NameSST
Protein NameGrowth hormone release inhibiting factor; Growth hormone release-inhibiting factor; Prepro somatostatin; SMS_HUMAN; SMST; Somatostatin 14; Somatostatin 28; Somatostatin-14; SST
Other NameGrowth hormone release inhibiting factor; / Growth hormone release-inhibiting factor; / Prepro somatostatin; / SMS_HUMAN; / SMST; / Somatostatin 14; / Somatostatin 28; / Somatostatin-14; / SST
SpeciesHuman
Gene ID-16750
UniprotP61278,
Species.1Mouse
Gene ID-220604
Uniprot.1P60041,
Species.2Rat
Gene ID-324797
Uniprot.2P60042
Organism-4
Gene ID-4
SwissProt-4
BackgroundThe hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008],
Cellular LocalizationCytoplasmic
Tissue ExpressionPancreas
Signaling_pathwayOrganismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas>>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Growth hormone synthesis, secretion and action; / >>Gastric acid secretion
FunctionFunction:Somatostatin inhibits the release of somatotropin.,online information:Somatostatin entry,pharmaceutical:A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.,similarity:Belongs to the somatostatin family.,
RRID
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