U-Blot® SREBP-1 Monoclonal Antibody
UcallM
$999.00
Product details
Background:Suz12 (Suppressor-of-Zeste 12 protein, also designated as ChET9, JJAZ1 protein) is a component of the Polycomb group complexes 2, 3 and 4 ( PRC2 , PRC3 and PRC4), which also contain the histone methyltransferase EZH2 , EED (Embryonic Ectoderm Development protein) protein and the histone-binding proteins RbAP46 and RbAP48 . PRC2 is responsible for di- and trimethylation of histone 3 at lysine 27 ( Histone H3K27me2 and Histone H3K27me3 ), which leads to transcriptional repression of the target genes. Suz12 is a nuclear protein belonging to the VEFS family. Suz12 contains a zinc-finger binding motif and a VEFS box, which is required for the interaction between Suz12 and EZH2.
Specifications
| Target | -- |
| Reactivity | Human |
| Applications | ChIP; WB; IP; EMSA |
| MW(Calculated) | 68 and 125 kDa |
| Host Species | Mouse |
| Isotype | IgG |
| Recommended Dilution Ratio | -- |
| Formulation | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| Purification | Protein G Chromatography |
| Storage | Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage. |
| Concentration | -- |
| Clonality | Monoclonal |
| Clone Number | IgG-2A4 |
| Immunogen | This SREBP-1 antibody was raised against a recombinant protein corresponding to amino acids 301-407 of human SREBP-1. |
| Specificity | -- |
| Gene Name | -- |
| Other Name | Sterol regulatory element-binding protein 1, SREBF1, bHLHd1, SREBP-1c |
| Gene ID | -- |
| Cellular Localization | -- |
| Function | -- |
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