Name: U-Blot® TCR Vδ2 Mouse mAb
SKU: WM1862
Price: 268 USD
Availability: InStock

U-Blot® TCR Vδ2 Mouse mAb

Ucallm_WM1862-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WM1862-50

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Product details

Background：
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	TCR Vδ2
Reactivity	Human
Applications	FC, IF
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	Mouse IgG1/Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Formulation	PBS, pH 7.4
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration	0.5mg/ml
Clonality	Monoclonal
Clone Number	RMMF0117
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	TRDC
Protein Name	T cell receptor delta variable 2/TRDV2
Other Name	T cell receptor delta constant,TCR Vδ2,
Species
Gene ID
Uniprot
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell membrane .
Tissue Expression
Signaling_pathway
Research Areas
Function	Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).