Name: UBE1L Monoclonal Antibody
SKU: WM0460
Price: 268 USD
Availability: InStock

UBE1L Monoclonal Antibody

Ucallm_WM0460-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM0460-50

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Product details

Background:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008],

Specifications

Target	UBE1L
Reactivity	Human
Applications	WB, ELISA
MW(Calculated)	112kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	Affinity purification
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	4F8
Immunogen	Purified recombinant fragment of human UBE1L expressed in E. Coli.
Sequence
Specificity	UBE1L Monoclonal Antibody detects endogenous levels of UBE1L protein.
Gene Name	UBA7
Protein Name	Ubiquitin-like modifier-activating enzyme 7
Other Name	UBA7; / UBE1L; / UBE2; / Ubiquitin-like modifier-activating enzyme 7; / Ubiquitin-activating enzyme 7; / D8; / Ubiquitin-activating enzyme E1 homolog
Species	Human
Gene ID-1	7318
Uniprot	P41226
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008],
Cellular Localization	nucleus,nucleoplasm,cytosol,
Tissue Expression	Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
Signaling_pathway	Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis
Research Areas	>>Ubiquitin mediated proteolysis; / >>Parkinson disease; / >>Pathways of neurodegeneration - multiple diseases
Function	Function:Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.,miscellaneous:There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-activating E1 family.,subunit:Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.,tissue specificity:Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.,
RRID

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UBE1L Monoclonal Antibody

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UBE1L Monoclonal Antibody

Product details

Specifications

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