SKU: WP1691 Categories: ,

ULK4 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1691-100
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Product details

Background:

This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016],

Specifications

Size50μL/100μL
TargetULK4
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)140kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityULK4 Polyclonal Antibody detects endogenous levels of protein.
Gene NameULK4
Protein NameSerine/threonine-protein kinase ULK4 (Unc-51-like kinase 4)
Other Name
SpeciesHuman
Gene ID54986
UniprotQ96C45,
Species.1Mouse
Gene ID.1
Uniprot.1Q3V129
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Tissue ExpressionExpressed in the brain, mainly in postmitotic neurons, including GABAergic neurons, but not in astrocytes (at protein level).
Signaling_pathway
Research Areas
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 HEAT repeats.,
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