Price range: $268.00 through $328.00
Background:
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | UN45A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 104kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human UN45A AA range: 259-309 |
| Specificity | This antibody detects endogenous levels of UN45A at Human/Mouse/Rat |
| Gene Name | UNC45A SMAP1 |
| Protein Name | UN45A |
| Other Name | |
| Species | Human |
| Gene ID | 55898 |
| Uniprot | Q9H3U1, |
| Species.1 | Mouse |
| Gene ID.1 | 101869 |
| Uniprot.1 | Q99KD5, |
| Species.2 | Rat |
| Gene ID.2 | 308759 |
| Uniprot.2 | Q32PZ3 |
| Cellular Localization | Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Predominant in the perinuclear region. Little protein in the nucleus. |
| Tissue Expression | Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen.,similarity:Contains 3 TPR repeats.,subcellular location:Predominant in the perinuclear region. Little protein in the nucleus.,subunit:Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.,tissue specificity:Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach., |
