USP11 Polyclonal Antibody
Ucallm_WP14945-50
Price range: $268.00 through $328.00
Product details
Background:
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | USP11 |
| Reactivity | Human, Mouse, Rat |
| Applications | IF, WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:50-200; WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications; |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from the Internal region of human USP11. |
| Specificity | USP11 Polyclonal Antibody detects endogenous levels of USP11 protein. |
| Gene Name | USP11 |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 11 |
| Other Name | USP11; / UHX1; / Ubiquitin carboxyl-terminal hydrolase 11; / Deubiquitinating enzyme 11; / Ubiquitin thioesterase 11; / Ubiquitin-specific-processing protease 11 |
| Species | Human |
| Gene ID | 8237 |
| Uniprot | P51784, |
| Species.1 | Mouse |
| Gene ID.1 | 236733 |
| Uniprot.1 | Q99K46 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Chromosome . Predominantly nuclear (PubMed:12084015, PubMed:15314155). Associates with chromatin (PubMed:20601937, PubMed:20233726). . |
| Tissue Expression | Brain,Fetal brain,Muscle,Retina, |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,subunit:Interacts with RANBP9/RANBPM., |
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