Price range: $268.00 through $328.00
Background:
This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
| Target | UTP14A |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human UTP14A. AA range:321-370 |
| Sequence | |
| Specificity | UTP14A Polyclonal Antibody detects endogenous levels of UTP14A protein. |
| Gene Name | UTP14A |
| Protein Name | U3 small nucleolar RNA-associated protein 14 homolog A |
| Other Name | UTP14A; / SDCCAG16; / U3 small nucleolar RNA-associated protein 14 homolog A; / Antigen NY-CO-16; / Serologically defined colon cancer antigen 16 |
| Species | Human |
| Gene ID-1 | 10813 |
| Uniprot | Q9BVJ6, |
| Species.1 | Mouse |
| Gene ID-2 | 72554 |
| Uniprot.1 | Q640M1 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009], |
| Cellular Localization | Nucleus, nucleolus . |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | >>Ribosome biogenesis in eukaryotes |
| Function | Function:May be required for ribosome biogenesis.,miscellaneous:The human genome also contains the UTP14C gene, an autosomal retrotransposed copy of this X-linked gene. Evolution of autosomal retrogenes from X-linked progenitors compensates for X-chromosome silencing during male meiosis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the UTP14 family.,tissue specificity:Ubiquitously expressed., |
| RRID |
