Price range: $268.00 through $328.00
Background:
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | VAMP4 |
| Reactivity | Human, Mouse |
| Applications | IF, ELISA |
| MW(Calculated) | 16kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications; |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VAMP4. AA range:1-50 |
| Specificity | VAMP-4 Polyclonal Antibody detects endogenous levels of VAMP-4 protein. |
| Gene Name | VAMP4 |
| Protein Name | Vesicle-associated membrane protein 4 |
| Other Name | VAMP4; / Vesicle-associated membrane protein 4; / VAMP-4 |
| Species | Human |
| Gene ID | 8674 |
| Uniprot | O75379, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O70480 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein . Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles. |
| Tissue Expression | B-cell,Bone marrow,Epithelium,Liver,Urinary bladder, |
| Signaling_pathway | |
| Research Areas | >>SNARE interactions in vesicular transport |
| Function | Function:Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.,subunit:Identified in a complex containing STX6, STX13, VAMP4 and VTI1A., |
