VLDLR Polyclonal Antibody
Ucallm_WP1940-50
Price range: $268.00 through $328.00
Product details
Background:
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009],
Specifications
| Size | 50μL/100μL |
| Target | VLDLR |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 96kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | VLDLR Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | VLDLR |
| Protein Name | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) |
| Other Name | |
| Species | Human |
| Gene ID | 7436 |
| Uniprot | P98155, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P98156, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P98166 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. |
| Tissue Expression | Abundant in heart and skeletal muscle; also ovary and kidney; not in liver. |
| Signaling_pathway | Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia |
| Research Areas | >>Spinocerebellar ataxia; / >>Lipid and atherosclerosis |
| Function | Disease:Deletions involving VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH) [MIM:224050]; also known as dysequilibrium syndrome (DES) or non-progressive cerebellar disorder with mental retardation. VLDLRCH is a syndrome characterized by moderate-to-profound mental retardation, delayed ambulation, and predominantly truncal ataxia. Additional features include strabismus and pesplanus in the majority of patients, seizures in 40% of patients, and short stature in 15% of patients. Magnetic resonance imaging demonstrates inferior cerebellar hypoplasia and mild cortical gyral simplification.,Function:Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.,similarity:Contains 3 EGF-like domains.,similarity:Contains 6 LDL-receptor class B repeats.,similarity:Contains 8 LDL-receptor class A domains.,subunit:Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains.,tissue specificity:Abundant in heart and skeletal muscle; also ovary and kidney; not in liver., |
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