VRK2 Polyclonal Antibody
Ucallm_WP15004-50
Price range: $268.00 through $328.00
Product details
Background:
vaccinia related kinase 2(VRK2) Homo sapiens This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014],
Specifications
| Size | 50μL/100μL |
| Target | VRK2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VRK2. AA range:171-220 |
| Specificity | VRK2 Polyclonal Antibody detects endogenous levels of VRK2 protein. |
| Gene Name | VRK2 |
| Protein Name | Serine/threonine-protein kinase VRK2 |
| Other Name | VRK2; / Serine/threonine-protein kinase VRK2; / Vaccinia-related kinase 2 |
| Species | Human |
| Gene ID | 7444 |
| Uniprot | Q86Y07, |
| Species.1 | Mouse |
| Gene ID.1 | 69922 |
| Uniprot.1 | Q8BN21 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cytoplasm . Endoplasmic reticulum membrane; Single-pass type IV membrane protein . Mitochondrion membrane; Single-pass type IV membrane protein . Nucleus envelope .; [Isoform 2]: Cytoplasm . Nucleus . |
| Tissue Expression | Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Probable serine/threonine kinase.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis., |
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