Name: WBSCR11 Polyclonal Antibody
SKU: WP15013
Price: 268 USD
Availability: InStock

Product details

Background:

The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010],

Specifications

Target	WBSCR11
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	106kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human GTF2IRD1. AA range:71-120
Sequence
Specificity	WBSCR11 Polyclonal Antibody detects endogenous levels of WBSCR11 protein.
Gene Name	GTF2IRD1
Protein Name	General transcription factor II-I repeat domain-containing protein 1
Other Name	GTF2IRD1; / CREAM1; / GTF3; / MUSTRD1; / RBAP2; / WBSCR11; / WBSCR12; / General transcription factor II-I repeat domain-containing protein 1; / GTF2I repeat domain-containing protein 1; / General transcription factor III; / MusTRD1/BEN; / Muscle TFII-I repeat do
Species	Human
Gene ID-1	9569
Uniprot	Q9UHL9,
Species.1	Mouse
Gene ID-2	57080
Uniprot.1	Q9JI57
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010],
Cellular Localization	Nucleus.
Tissue Expression	Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.
Signaling_pathway
Research Areas	>>Basal transcription factors; / >>cGMP-PKG signaling pathway
Function	developmental stage:Highly expressed in developing and regenerating muscles, at the time of myofiber diversification.,Disease:Haploinsufficiency of GTF2IRD1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Domain:The N-terminal half may have an activating activity.,Function:May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the TFII-I family.,similarity:Contains 5 GTF2I-like repeats.,subunit:Interacts with the retinoblastoma protein (RB1) via its C-terminus.,tissue specificity:Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.,
RRID

Please login to post questions

WBSCR11 Polyclonal Antibody

Product details

Specifications

About Us

Support

Order

Menu

WBSCR11 Polyclonal Antibody

Product details

Specifications

Related products

U-Blot® CD86 Rabbit mAb

U-Blot™ SSPE buffer, pH 7.4

U-Blot® Glutamine Synthetase Rabbit mAb

U-Blot® VEGF Receptor 1 Rabbit mAb

U-Blot® GSK3 β (Phospho Ser9) Rabbit mAb

U-Blot® Tuberin Rabbit mAb

Customer Reviews

Menu