Price range: $268.00 through $328.00
Background:
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015],
| Specification | 50μL;100μL |
| Target | XRCC4 |
| Reactivity | Human |
| Applications | WB, IHC, IF, IP |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate | |
| Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000;IP 1:200;IF 1:200;IHC 1:50-300 |
| Composition | PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. |
| Source | |
| Purification Process | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Puity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 5C10 |
| Immunogen | Synthetic Peptide of XRCC4 |
| Sequence | |
| Specificity | The antibody detects endogenous XRCC4 proteins. |
| Gene Name | XRCC4 |
| Protein Name | DNA repair protein XRCC4 |
| Alias | XRCC4;DNA repair protein XRCC4;X-ray repair cross-complementing protein 4 |
| Organism-1 | Human |
| Gene ID-1 | 7518 |
| SwissProt-1 | Q13426 |
| Organism-2 | Mouse |
| Gene ID-2 | 108138 |
| SwissProt-2 | Q924T3 |
| Organism-3 | |
| Gene ID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | Nucleus . Chromosome . Localizes to site of double-strand breaks. .; [Protein XRCC4, C-terminus]: Cytoplasm . Translocates from the nucleus to the cytoplasm following cleavage by caspase-3 (CASP3). . |
