Name: ZNRF2 Polyclonal Antibody
SKU: WP15092
Price: 268 USD
Availability: InStock

ZNRF2 Polyclonal Antibody

Ucallm_WP15092-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP15092-100

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:

domain:The RING-type zinc finger domain is required for E3 ligase activity., function:May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., pathway:Protein modification; protein ubiquitination., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 RING-type zinc finger., subcellular location:Present in presynaptic plasma membranes in neurons., subunit:Interacts with UBE2N., tissue specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.,

Specifications

Size	50μL/100μL
Target	ZNRF2
Reactivity	Human, Mouse
Applications	IHC, IF, ELISA
MW(Calculated)	24kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ZNRF2. AA range:161-210
Specificity	ZNRF2 Polyclonal Antibody detects endogenous levels of ZNRF2 protein.
Gene Name	ZNRF2
Protein Name	E3 ubiquitin-protein ligase ZNRF2
Other Name	ZNRF2; / RNF202; / E3 ubiquitin-protein ligase ZNRF2; / Protein Ells2; / RING finger protein 202; / Zinc/RING finger protein 2
Species	Human
Gene ID	223082
Uniprot	Q8NHG8,
Species.1	Mouse
Gene ID.1	387524
Uniprot.1	Q71FD5
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Endosome membrane; Peripheral membrane protein . Lysosome membrane; Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein .
Tissue Expression	Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.
Signaling_pathway
Research Areas
Function	Domain:The RING-type zinc finger domain is required for E3 ligase activity.,Function:May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Present in presynaptic plasma membranes in neurons.,subunit:Interacts with UBE2N.,tissue specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.,