Name: U-Blot® PLZF Rabbit mAb
SKU: WR5170
Price: 268 USD
Availability: InStock

U-Blot® PLZF Rabbit mAb

Ucallm_WR5170-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5170-100

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Product details

Background:This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	PLZF
Reactivity	Human
Applications	WB, IF, ELISA
MW(Calculated)	74kD
MW(Observed)	80kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1404R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	ZBTB16
Protein Name	Zinc finger and BTB domain-containing protein 16
Other Name	ZBTB16; / PLZF; / ZNF145; / Zinc finger and BTB domain-containing protein 16; / Promyelocytic leukemia zinc finger protein; / Zinc finger protein 145; / Zinc finger protein PLZF
Species	Human
Gene ID	7704
Uniprot	Q05516
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus . Nucleus, nuclear body .
Tissue Expression	Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.
Signaling_pathway	Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia
Research Areas	>>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia
Function	Disease:A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11; 17)(q32; q21) with RARA.,Disease:Defects in ZBTB16 are the cause of skeletal defects genital hypoplasia and mental retardation [MIM:612447]. The disorder is characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.,Function:Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,induction:By retinoic acid.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 9 C2H2-type zinc fingers.,subunit:Binds EPN1. Interacts with ZBTB32 and CUL3.,tissue specificity:Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.,

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U-Blot® PLZF Rabbit mAb

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U-Blot® PLZF Rabbit mAb

Product details

Specifications

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