Name: U-Blot® ALPP Rabbit mAb
SKU: WR4291
Price: 268 USD
Availability: InStock

U-Blot® ALPP Rabbit mAb

Western blot analysis of lysates from Hela cells, using ALPP Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002,) was used to detect the antibody.

WR4291 Western blot analysis of lysates from Hela cells, using ALPP Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4291-50

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Product details

Background:The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015],

Specifications

Size	50μL/100μL
Target	PLAP
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	58kD
MW(Observed)	70kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0484R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	ALPP; PLAP
Protein Name	Alkaline phosphatase, placental type
Other Name	ALPP; / PLAP; / Alkaline phosphatase; / placental type; / Alkaline phosphatase Regan isozyme; / Placental alkaline phosphatase 1; / PLAP-1
Species	Human
Gene ID	250
Uniprot	P05187
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Membrane
Tissue Expression	Detected in placenta (at protein level).
Signaling_pathway
Research Areas	>>Thiamine metabolism; / >>Folate biosynthesis; / >>Metabolic pathways; / >>Biosynthesis of cofactors
Function	Catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,polymorphism:Placental ALP is highly polymorphic, there are at least three common alleles.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer.,