Name: U-Blot® Beclin 1 Rabbit mAb
SKU: WR4306
Price: 268 USD
Availability: InStock

U-Blot® Beclin 1 Rabbit mAb

Western blot analysis of lysates from Hela cells, using Beclin 1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002,) was used to detect the antibody.

WR4306 Western blot analysis of lysates from Hela cells, using Beclin 1 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002,) was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4306-50

Enter the quantity you would like, or drag the panel to find the quantity and price that best for you

Bulk Quote Authorize OEM & ODM

Product details

Background:beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

Specifications

Size	50μL/100μL
Target	Beclin 1
Reactivity	Human, Mouse, Rat, Chicken
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	52kD
MW(Observed)	60kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0506R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	BECN1 GT197
Protein Name	Beclin-1
Other Name	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197)
Species	Human
Gene ID	8678
Uniprot	Q14457,
Species.1	Mouse
Gene ID.1	56208
Uniprot.1	O88597,
Species.2	Rat
Gene ID.2	114558
Uniprot.2	Q91XJ1
Cellular Localization	Cytoplasm
Tissue Expression	Ubiquitous.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Research Areas	>>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal; / >>Apoptosis - multiple species; / >>Apelin signaling pathway; / >>Alzheimer disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis; / >>Kaposi sarcoma-associated herpesvirus infection
Function	Function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous.,

Please login to post questions

U-Blot® Beclin 1 Rabbit mAb

Product details

Specifications

About Us

Support

Order

Menu

U-Blot® Beclin 1 Rabbit mAb

Product details

Specifications

Related products

U-Blot® CDK6 Rabbit mAb

U-Blot® GSK3 β (Phospho Ser9) Rabbit mAb

U-Blot™ Universal Antibody Dilution Buffer

U-Blot® FOXO3A (Phospho Ser253) Rabbit mAb

Acetyl Lysine Monoclonal Antibody [10B10]

U-Blot® VEGF Receptor 1 Rabbit mAb

Customer Reviews

Menu