Product details

Background:
CD43 is a transmembrane protein related to T cell immune function. It mainly marks T cells and is expressed in normal T lymphocytes, macrophages, myelocytes and plasma cells, but not in normal B cells or reactive B cells. It is expressed in all of the extramedullary myeloma and granulocytic sarcoma, most of the T-lymphocytic lymphoma, acute T-lymphocytic leukemia and acute B-lymphocytic leukemia, some of the low-grade B-cell lymphoma and anaplastic large cell lymphoma.

Specifications

Target	CD43
Reactivity	Human
Applications	IHC, WB, IF, ELISA
MW(Calculated)	40kD
MW(Observed)	90kD
Host Species	Mouse
Isotype	IgG2b,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	ABT027
Immunogen	Synthesized peptide derived from human CD43 AA range: 300-400
Sequence
Specificity	The antibody can specifically recognize human CD43 protein.
Gene Name	SPN CD43
Protein Name	Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]
Other Name	CD 43; / CD43; / CD43 antigen; / Galactoglycoprotein; / GALGP; / GPL 115; / GPL115; / Human gene for sialophorin; / Leucocyte sialoglycoprotein; / LEUK_HUMAN; / Leukocyte large sialoglycoprotein; / Leukocyte sialoglycoprotein; / Leukosialin; / LSN; / Ly-48; / sialophorin; / gpL115, leukosialin, CD43; / Sialophorin; / Spn
Species	Human
Gene ID-1	6693
Uniprot	P16150
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	CD43 is a transmembrane protein related to T cell immune function. It mainly marks T cells and is expressed in normal T lymphocytes, macrophages, myelocytes and plasma cells, but not in normal B cells or reactive B cells. It is expressed in all of the extramedullary myeloma and granulocytic sarcoma, most of the T-lymphocytic lymphoma, acute T-lymphocytic leukemia and acute B-lymphocytic leukemia, some of the low-grade B-cell lymphoma and anaplastic large cell lymphoma.
Cellular Localization	Membranous
Tissue Expression	Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Signaling_pathway	Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas	>>Cell adhesion molecules
Function	Disease:CD43 expression is defective on the T-cells of males with the immunodeficiency Wiskott-Aldrich syndrome. Affected males are susceptible to opportunistic infections and do not respond to polysaccharide antigens, reflecting defects in cytotoxic and helper T-cell functions.,Function:One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.,PTM:Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.,subunit:Interacts with HIPK2 via the cytoplasmic domain.,tissue specificity:Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.,
RRID

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CD43 [ABT027] mouse mAb

Product details

Specifications

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CD43 [ABT027] mouse mAb

Product details

Specifications

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