SKU: WN0172 Categories: ,

Recombinant CD206 Fc-Fused Nanobody (VF0061)

$365.00

SKU: WN0172
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Product details

Background:The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded byThis gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]

Specifications

Size100μL
TargetCD33
ReactivityHuman
ApplicationsFC, ELISA
MW(Calculated)
MW(Observed)
Host Species
IsotypeIgG2a,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioELISA 1:5000-100000; Flow Cyt 1-2μg/Test
FormulationPhosphate-buffered solution
PurificationRecombinant Expression and Affinity purified
Storage-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
ConcentrationPlease check the information on the tube
Clonality
Clone NumberVF0117
ImmunogenPurified recombinant Human CD206
SpecificityThis recombinant monoclonal antibody can detects endogenous levels of CD206 protein.
Gene NameMRC1 CLEC13D CLEC13DL MRC1L1
Protein NameMacrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)
Other NameMRC1; / CLEC13D; / CLEC13DL; / MRC1L1; / Macrophage mannose receptor 1; / MMR; / C-type lectin domain family 13 member D; / C-type lectin domain family 13 member D-like; / Macrophage mannose receptor 1-like protein 1; / CD206
SpeciesHuman
Gene ID945
UniprotP22897
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationEndosome membrane; Single-pass type I membrane protein . Cell membrane; Single-pass type I membrane protein .
Tissue ExpressionMonocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Signaling_pathwayOrganismal Systems >> Immune system >> Hematopoietic cell lineage
Research Areas
FunctionMediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,
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