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Background:This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein.This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]
| Size | 100μL |
| Target | CD325 |
| Reactivity | Human |
| Applications | FC, ELISA |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | |
| Isotype | IgG2a,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | ELISA 1:5000-100000; Flow Cyt 1-2μg/Test |
| Formulation | Phosphate-buffered solution |
| Purification | Recombinant Expression and Affinity purified |
| Storage | -15°C to -25°C/1 year(Avoid freeze / thaw cycles) |
| Concentration | Please check the information on the tube |
| Clonality | |
| Clone Number | VF0414 |
| Immunogen | Purified recombinant Human CD325 |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD325 protein. |
| Gene Name | CDH2 CDHN NCAD |
| Protein Name | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) |
| Other Name | CADH2_HUMAN antibody; / Cadherin 2 antibody; / Cadherin 2 N cadherin neuronal antibody; / Cadherin 2 type 1 antibody; / Cadherin 2 type 1 N cadherin neuronal antibody; / Cadherin 2; / type 1; / N-cadherin; / neuronal; / antibody; / Cadherin-2 antibody; / Cadherin2 antibody; / Calcium dependent adhesion protein neuronal antibody; / CD325 antibody; / CD325 antigen antibody; / CDH2 antibody; / CDHN antibody; / CDw325 antibody; / CDw325 antigen antibody; / N cadherin 1 antibody; / N-cadherin antibody; / NCAD antibody; / Neural cadherin antibody; / OTTHUMP00000066304 antibody; / OTTHUMP00000067378 antibody; / CD325 nanobody |
| Species | Human |
| Gene ID | 1000 |
| Uniprot | P19022 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Cell membrane, sarcolemma . Cell junction . Cell surface . Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. . |
| Tissue Expression | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules |
| Research Areas | |
| Function | Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism.,similarity:Contains 5 cadherin domains.,subunit:Interacts with CDCP1., |
