Cell membrane; Single-pass type I membrane protein.
Tissue Expression
CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.
Signaling_pathway
Organismal Systems >> Immune system >> Hematopoietic cell lineage
Research Areas
Function
May act as a receptor in regulating T-cell proliferation. CD5 interacts with CD72/LYB-2.,similarity:Contains 3 SRCR domains.,