Name: U-Blot® Claudin 4 Rabbit mAb
SKU: WR4998
Price: 268 USD
Availability: InStock

U-Blot® Claudin 4 Rabbit mAb

Ucallm_WR4998-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR4998-50

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Product details

Background:The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Sep 2013],

Specifications

Size	50μL/100μL
Target	Claudin-4
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	22kD
MW(Observed)	18kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:100-1:500; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1230R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	CLDN4
Protein Name	Claudin-4
Other Name	CLDN4; / CPER; / CPETR1; / WBSCR8; / Claudin-4; / Clostridium perfringens enterotoxin receptor; / CPE-R; / CPE-receptor; / Williams-Beuren syndrome chromosomal region 8 protein
Species	Human
Gene ID	1364
Uniprot	O14493,
Species.1	Mouse
Gene ID.1	12740
Uniprot.1	O35054
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cell junction, tight junction . Cell membrane; Multi-pass membrane protein . CLDN4 is required for tight junction localization in the kidney. .
Tissue Expression	Colon,Fetal brain,Trachea,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas	>>Cell adhesion molecules; / >>Tight junction; / >>Leukocyte transendothelial migration; / >>Pathogenic Escherichia coli infection; / >>Hepatitis C
Function	Disease:Haploinsufficiency of CLDN4 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,

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U-Blot® Claudin 4 Rabbit mAb

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U-Blot® Claudin 4 Rabbit mAb

Product details

Specifications

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