Price range: $268.00 through $328.00
Background:
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010],
| Size | 50μL/100μL |
| Target | DNJC3 |
| Reactivity | Human, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 80-160 |
| Specificity | DNJC3 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | DNAJC3 P58IPK PRKRI |
| Protein Name | DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DnaJ protein 6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58) |
| Other Name | |
| Species | Human |
| Gene ID | 5611 |
| Uniprot | Q13217, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q91YW3, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q9R0T3 |
| Cellular Localization | Endoplasmic reticulum . |
| Tissue Expression | Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels. |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | >>Protein processing in endoplasmic reticulum; / >>Influenza A |
| Function | Domain:The J domain mediates interaction with HSPA8.,Function:Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.,induction:Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK.,similarity:Contains 1 J domain.,similarity:Contains 9 TPR repeats.,subunit:Interacts with EIF2AK3 (By similarity) and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK.,tissue specificity:Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels., |
