Price range: $268.00 through $328.00
Background:
keratin 9(KRT9) Homo sapiens This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | K1C9 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 68kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 340-420 |
| Specificity | K1C9 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | KRT9 |
| Protein Name | Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9) |
| Other Name | |
| Species | Human |
| Gene ID | 3857 |
| Uniprot | P35527, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q6RHW0, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q8CIS9 |
| Cellular Localization | extracellular space,nucleus,intermediate filament,membrane,extracellular exosome, |
| Tissue Expression | Expressed in the terminally differentiated epidermis of palms and soles. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Estrogen signaling pathway |
| Research Areas | >>Estrogen signaling pathway; / >>Staphylococcus aureus infection |
| Function | Caution:Was originally (PubMed:2140676) thought to be a 60 kDa chain of placental scatter protein.,Disease:Defects in KRT9 are a cause of palmoplantar keratoderma epidermolytic (EPPK) [MIM:144200]; also abbreviated EHPPK. EPPK is a dermatological disorder characterized by diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous margins.,Disease:Knuckle pads are sometimes associated with EPPK [MIM:149100]. Knuckle pads consist of an autosomal dominant trait, in which thick pads of skin appear over the proximal phalangeal joints.,Function:May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.,induction:Induced by intrinsic regulatory mechanisms and by extrinsic signals from a subset of dermal palmoplantar fibroblasts.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Expressed in the terminally differentiated epidermis of palms and soles., |
